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Electroacupuncture improves upper-limb motor function and modulates sensorimotor network connectivity in subacute

Mingfen Li¹, Weigeng Zou¹, Genggeng Xie¹

¹Department of Neurorehabilitation, Hubei Provincial Clinical Research Center for Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

Frontiers in Neurology

|July 6, 2026

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Electroacupuncture (EA) significantly improved upper-limb motor function in subacute stroke patients by enhancing sensorimotor network (SMN) connectivity. This neurophysiological change suggests EA aids recovery through specific circuit reorganization.

Area of Science:

Neuroscience
Rehabilitation Medicine
Biomedical Engineering

Background:

Post-stroke motor recovery remains a challenge, with limited understanding of neurophysiological mechanisms.
Electroacupuncture (EA) shows potential in facilitating motor recovery, but its effects on brain networks are unclear.

Purpose of the Study:

To investigate how EA modulates sensorimotor network (SMN) functional connectivity (FC).
To explore the relationship between EA-induced FC changes and upper-limb motor recovery in subacute stroke patients.

Main Methods:

Fifty subacute stroke patients were randomized into EA and sham EA (SEA) groups.
Resting-state EEG recorded FC (alpha and beta bands) and graph-theoretical metrics before and after 3 weeks of treatment.
Partial least squares regression (PLSR) assessed the link between FC alterations and motor improvement.

Keywords:

electroacupuncture electroencephalography neuroplasticity stroke rehabilitation upper-limb

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Main Results:

The EA group showed significantly greater upper-limb motor function improvement (FMA-UE) than the SEA group.
EA treatment led to a significant increase in alpha-band SMN FC, particularly interhemispheric connections.
PLSR explained 68.7% of motor improvement variance in the EA group, linked to alpha-band FC.

Conclusions:

EA enhances upper-limb motor recovery in subacute stroke.
EA is associated with selective enhancement of alpha-band FC within the SMN.
EA may promote recovery via frequency-specific reorganization of sensorimotor circuits.