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Related Experiment Video

Updated: Jul 7, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Early Findings from the Multicenter RAPID Consortium on Papillary Craniopharyngiomas.

Michael P Catalino1,2, Duy Pham1, Robert C Rennert3

  • 1Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, United States.

Journal of Neurological Surgery. Part B, Skull Base
|July 6, 2026
PubMed

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Summary
This summary is machine-generated.

Papillary craniopharyngiomas (PCPs) are rare tumors. Gross total resection (GTR) and pituitary stalk preservation are crucial for favorable outcomes in PCPs, as supported by the RAPID registry data.

Area of Science:

  • Neurosurgery
  • Endocrinology
  • Oncology

Background:

  • Papillary craniopharyngiomas (PCPs) are rare tumors occurring in the parasellar region, accounting for 8-20% of craniopharyngiomas.
  • This study analyzes data from the Registry of Adenomas of the Pituitary and Related Disorders (RAPID) to understand PCP characteristics and outcomes.

Purpose of the Study:

  • To analyze demographic, imaging, surgical, and outcome data for patients with papillary craniopharyngiomas.
  • To identify factors associated with treatment success and complications in PCPs.

Main Methods:

  • Retrospective analysis of data from 99 patients with PCPs across 14 U.S. academic skull base centers (2011-2023).
  • Data included tumor characteristics, surgical approaches (predominantly endoscopic endonasal), extent of resection (gross total resection - GTR), pituitary stalk preservation, complications, and adjuvant therapy.
Keywords:
RAPIDendocrinology outcomesextent of resectionmulticenteroutcomespapillary craniopharyngiomaregistrystalk preservationsurgery

Related Experiment Videos

Last Updated: Jul 7, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

  • Analysis of BRAF V600E mutation status and its correlation with treatment.

    • Main Results:

    • Most PCPs had mixed cystic/solid components and were treated via endoscopic endonasal approach, with 51.1% achieving GTR.
    • Permanent arginine vasopressin deficiency was common (67.1%) and associated with pituitary stalk sacrifice (p=0.003).
    • Cerebrospinal fluid leak was the most frequent complication (9.1%). GTR correlated with reduced radiotherapy use (p=0.0001). BRAF V600E mutation was prevalent (64/69 tested).

    Conclusions:

    • The RAPID consortium provides a valuable dataset for studying PCPs.
    • Gross total resection and pituitary stalk preservation are key factors influencing patient outcomes.
    • This data can inform future research frameworks for multicenter registries.