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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
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Multilevel Work Environment Factors and Occupational Well-Being Among APRNs Delivering Opioid Use Disorder Treatment:
Zhanette Coffee1,2,3, Chandra Speight4, Lisa M Reyes-Walsh5
1College of Nursing, University of Arizona, Tucson, AZ, USA.
Substance Use : Research and Treatment
|July 6, 2026
Summary
Advanced practice registered nurses (APRNs) providing opioid use disorder (OUD) treatment face significant burnout, stress, and vicarious trauma. Positive organizational climate and specific training are key to improving confidence and reducing strain in OUD care.
Area of Science:
- Nursing
- Public Health
- Psychiatry
Background:
- Advanced practice registered nurses (APRNs) are vital in delivering opioid use disorder (OUD) treatment.
- Factors influencing APRNs' ability to provide OUD care are not well understood.
Purpose of the Study:
- To investigate the associations between psychosocial and organizational factors and the delivery of OUD treatment by APRNs.
Main Methods:
- A multistate cross-sectional study surveyed 400 APRNs on stress, burnout, vicarious trauma, stigma, organizational climate, training, and confidence in OUD care.
- Data were analyzed using descriptive statistics, correlations, and multivariable linear regression, guided by the Job Demands-Resources (JD-R) framework.
Main Results:
- 41% of APRNs reported burnout; younger age and minority status correlated with higher stress and burnout.
- Perceived patient stigma increased stress and burnout, while a positive organizational climate decreased them.
- Vicarious trauma showed the strongest association with burnout and stress; organizational climate and X-waiver training positively impacted confidence in OUD care.
Conclusions:
- APRNs in OUD treatment experience significant occupational strain linked to vicarious trauma, stigma, and organizational factors.
- Further research is needed to support APRNs and enhance their engagement in OUD care delivery.
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