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Published on: May 2, 2025
Cardiac output measurement in Fontan circulation: Challenges and potential emerging solutions
Ashish H Shah1, Veena Bharathi Kota2, Sivasubramanian Ramakrishnan2
1Department of Internal Medicine, Section of Cardiology, University of Manitoba, Winnipeg, MB, Canada.
Insights
Accurate cardiac output (CO) measurement is vital for Fontan patients. This review explores challenges with current methods and highlights the need to validate noninvasive impedance cardiography for this population.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Accurate cardiac output (CO) assessment is crucial for managing Fontan patients' hemodynamic status.
- Established CO measurement techniques (Fick, thermodilution, echocardiography, MRI) have significant limitations in Fontan physiology.
- Noninvasive impedance cardiography (ICG) presents a potential alternative but requires validation in Fontan patients.
Purpose of the Study:
- To review the limitations of current CO assessment methods in Fontan patients.
- To highlight the potential of impedance cardiography (ICG) as a noninvasive CO monitoring tool.
- To emphasize the need for further research and validation of ICG in pediatric and adult Fontan populations.
Main Methods:
- Literature review of existing cardiac output assessment methodologies.
- Analysis of Fontan-specific anatomical and physiological challenges impacting CO measurement.
- Evaluation of the current evidence and limitations of impedance cardiography in Fontan patients.
Main Results:
- Traditional CO methods face significant challenges due to Fontan's unique anatomy and physiology.
- Impedance cardiography (ICG) offers a promising noninvasive approach but lacks extensive validation in this cohort.
- There is a critical need for refining and validating ICG for reliable CO monitoring in Fontan patients.
Conclusions:
- Existing CO measurement techniques are inadequate for Fontan patients.
- Impedance cardiography (ICG) requires rigorous validation to become a reliable tool for Fontan CO assessment.
- Further research is essential to improve hemodynamic management in Fontan patients through validated noninvasive monitoring.
Abstract:
Similar to other cardiovascular conditions, accurate cardiac output (CO) assessment in Fontan patients is critical for evaluation of hemodynamic state. However, traditional methodologies, including the Fick principle, thermodilution, Doppler echocardiography, and cardiac magnetic resonance imaging face substantial limitations due to Fontan-specific anatomy and physiology. Impedance cardiography-based technologies offer a noninvasive alternative, yet they remain undervalidated in this unique population. This review highlights the challenges of established methods and emphasizes the need to explore, refine, and validate impedance cardiography-based CO monitoring across pediatric and adult Fontan patients.
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