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Perinatal Arterial Ischemic Stroke Related to Internal Carotid Artery Occlusion: Two Case Reports

Jin Wang1, Yanping Huang1, Lingkong Zeng1

  • 1Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science & Technology Wuhan China.

Clinical Case Reports
|July 6, 2026
PubMed

Insights

Perinatal arterial ischemic stroke (PAIS) in neonates can be caused by internal carotid artery occlusion (ICAO). Early diagnosis via cervical imaging is crucial for managing this rare condition and its associated neurological deficits.

Area of Science:

  • Neurology
  • Pediatrics
  • Vascular Medicine

Background:

  • Perinatal arterial ischemic stroke (PAIS) is a significant cause of childhood neurological deficits.
  • Internal carotid artery occlusion (ICAO) is a rare but serious cause of PAIS in neonates.
  • ICAO often presents with subtle, atypical symptoms in newborns.

Purpose of the Study:

  • To report two cases of PAIS secondary to ICAO in neonates.
  • To highlight the diagnostic challenges and neurological outcomes associated with neonatal ICAO.
  • To emphasize the importance of early diagnosis for improved patient management.

Main Methods:

  • Case report of two neonates diagnosed with PAIS.
  • Clinical assessment and follow-up evaluations.
  • Cervical vascular imaging for diagnosis of ICAO.

Main Results:

  • Both neonates presented with PAIS attributed to ICAO.
  • Acute symptoms resolved upon discharge, but persistent limb hypokinesia was observed.
  • ICAO in neonates is associated with poor neurological outcomes.

Conclusions:

  • Neonatal ICAO is a rare cause of PAIS with insidious onset.
  • Comprehensive cervical vascular imaging is essential for diagnosing neonatal ICAO in PAIS cases.
  • Timely diagnosis and intervention are critical for managing neurological deficits in affected neonates.

Keywords:
case reportinternal carotid artery occlusionnewperinatal arterial ischemic stroke

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