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Association Between the Systemic Inflammatory Response Index and Severe Infection in Patients with Diabetic Foot
Ping Wu1,2, Wendong Xu3,4, Rui Chen3
1Department of Pharmacology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, People's Republic of China.
Summary
The Systemic Inflammatory Response Index (SIRI) strongly predicts severe diabetic foot infections (DFI). Maintaining a low SIRI level is crucial for preventing severe DFI in diabetes patients.
Area of Science:
- Medical research
- Inflammation markers
- Diabetic complications
Background:
- Diabetic foot infection (DFI) is a serious complication of diabetes.
- Assessing the severity of DFI is critical for timely and effective treatment.
- Novel biomarkers for predicting DFI severity are needed.
Purpose of the Study:
- To investigate the association between the Systemic Inflammatory Response Index (SIRI) and the severity of diabetic foot infections (DFI).
- To determine if SIRI can serve as a predictive marker for severe DFI.
Main Methods:
- Retrospective study of 242 DFI patients.
- Categorization into moderate (n=132) and severe (n=110) infection groups.
- Analysis using Receiver Operating Characteristic (ROC) curves, multivariate logistic regression, and restricted cubic spline (RCS) models.
Main Results:
- SIRI showed a high accuracy in predicting severe DFI (AUC = 0.959).
- Each 1-unit increase in SIRI elevated the risk of severe DFI by 2.26 times.
- A nonlinear association was observed, with increased risk beyond an inflection point of SIRI at 3.53.
Conclusions:
- SIRI is a significant predictor of DFI severity in diabetic patients.
- Maintaining a low SIRI level is essential for preventing severe DFI.
- Monitoring SIRI levels is important for managing diabetic foot patients.
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