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Gut microbiota as a therapeutic target in sepsis-induced multi-organ dysfunction: a review

Xinlan Zhao1, Tiangang Ma2, Jinyan Yu1

  • 1Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.

Frontiers in Cellular and Infection Microbiology
|July 6, 2026
PubMed

Insights

Gut microbiota translocation is key in sepsis and organ dysfunction. Understanding these interactions may reveal new therapeutic targets for sepsis treatment.

Area of Science:

  • Microbiology
  • Immunology
  • Critical Care Medicine

Background:

  • Sepsis and multiple organ dysfunction have high mortality rates.
  • Gut microbiota translocation is a critical factor in sepsis development and progression.
  • Inflammatory responses and antibiotic use in sepsis exacerbate gut microbiota issues.

Purpose of the Study:

  • To review the complex interactions between gut microbiota translocation, sepsis, and organ dysfunction.
  • To identify potential therapeutic targets for sepsis prevention and treatment.

Main Methods:

  • Literature review of studies from PubMed and Web of Science.
  • Synthesis of current research on gut microbiota and sepsis.

Main Results:

  • Gut microbiota translocation significantly contributes to sepsis progression.
  • Altered microbial metabolites and immune dysregulation are consequences of translocation.
  • This translocation exacerbates organ dysfunction in sepsis patients.

Conclusions:

  • Targeting gut microbiota translocation offers a promising avenue for sepsis treatment.
  • Further research into these interactions could lead to novel therapeutic strategies.
  • Addressing gut dysbiosis is crucial for improving sepsis outcomes.
Keywords:
gut microbiotainflammatory responsesintestinal barrier disruptionmulti-organ dysfunctionorgan damage

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