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Updated: Jul 7, 2026
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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
Published on: December 24, 2015
Measuring antiaging effects through changes in telomere length after mesenchymal stem cells therapy
1Gangnam Seran Clinic, Seoul, Korea.
Journal of Exercise Rehabilitation
|July 6, 2026
Summary
Intravenous mesenchymal stem cell (MSC) therapy consistently increased peripheral blood telomere length, a key biomarker for cellular aging. This suggests MSCs may offer anti-aging benefits and telomere length can guide patient selection for such therapies.
Area of Science:
- Gerontology
- Regenerative Medicine
- Molecular Biology
Background:
- Telomere length is a critical biomarker for cellular aging and biological age.
- Shortened telomeres are linked to age-related diseases and reduced regenerative capacity.
Purpose of the Study:
- To investigate the impact of intravenous mesenchymal stem cells (MSCs) administration on peripheral blood telomere length.
- To assess telomere length changes as a potential biomarker for MSCs-based anti-aging therapies.
Main Methods:
- Retrospective analysis of 19 cases (18 subjects) aged 34-78 years.
- Measurement of peripheral blood telomere length (kb/cell) before and after intravenous MSCs treatment.
- Evaluation of telomere elongation across various ages, sexes, and treatment durations (25 days to 14 months).
Main Results:
- Intravenous MSCs treatment demonstrated a consistent and measurable increase in peripheral blood telomere length.
- Telomere elongation was observed across diverse patient demographics and treatment durations.
Conclusions:
- Peripheral blood telomere length serves as a viable outcome biomarker for MSCs-based anti-aging interventions.
- Telomere length can be utilized as a patient selection criterion for anti-aging therapies involving MSCs.
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