Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MDA-9/Syntenin small molecule inhibitor IVMT-Rx-4 blocks prostate cancer bone metastasis.

Pharmacological research·2026
Same author

A systematic approach to develop and characterize a compositionally equivalent buprenorphine in situ forming implant (Sublocade®).

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Machine Learning Guided Optimization of an Oral Microemulsion System: A Bayesian Optimization Approach.

bioRxiv : the preprint server for biology·2026
Same author

Fenofibrate microemulsion eyedrops for treating nitrogen mustard induced corneal injury.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Nitric Oxide-Releasing Thixotropic Hydrogels as Antibacterial and Hemocompatible Catheter Locks.

ACS biomaterials science & engineering·2025
Same author

Oral Pharmacokinetic Evaluation of a Microemulsion-Based Delivery System for Novel A190 Prodrugs.

Biomolecules·2025
Same journal

Real-time in vivo tracking of nanoparticulate vaccines in inguinal lymph nodes.

AAPS open·2026
Same journal

Mastering particle size analysis: lessons, challenges, and future directions from the FDA-CRCG workshop.

AAPS open·2026
Same journal

Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections.

AAPS open·2026
Same journal

Investigating the impact of charge and hydrophilicity on peptide-mucin interactions using a simple mucin model.

AAPS open·2026
Same journal

Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin.

AAPS open·2025
Same journal

Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice.

AAPS open·2025
See all related articles

Related Experiment Video

Updated: Jul 7, 2026

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
13:54

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

Published on: August 18, 2023

Machine learning guided optimization of an oral microemulsion system: a Bayesian optimization approach.

Madeline Gunawardena1, Bao Chau2, Hayden Nothacker2

  • 1Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 USA.

AAPS Open
|July 6, 2026
PubMed
Summary
This summary is machine-generated.

Bayesian optimization streamlined microemulsion (ME) formulation design, identifying stable MEs with optimized properties. This approach enhances drug delivery for poorly soluble compounds.

Keywords:
Drug formulation developmentOral drug deliveryPhysicochemical regressionProperty predictionStability classification

More Related Videos

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

Optimization of An Air-Based Heat Management System for Dusty Particulate Matter-Covered Lithium-Ion Battery Packs
10:36

Optimization of An Air-Based Heat Management System for Dusty Particulate Matter-Covered Lithium-Ion Battery Packs

Published on: November 3, 2023

Related Experiment Videos

Last Updated: Jul 7, 2026

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
13:54

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

Published on: August 18, 2023

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

Optimization of An Air-Based Heat Management System for Dusty Particulate Matter-Covered Lithium-Ion Battery Packs
10:36

Optimization of An Air-Based Heat Management System for Dusty Particulate Matter-Covered Lithium-Ion Battery Packs

Published on: November 3, 2023

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Oral microemulsions (MEs) enhance oral bioavailability of poorly water-soluble drugs.
  • Current ME formulation is time-consuming and resource-intensive, often yielding suboptimal performance.
  • An unmet need exists for efficient ME design methods.

Purpose of the Study:

  • To develop an optimized method for designing microemulsions.
  • To streamline the microemulsion formulation development process.
  • To identify high-performing microemulsions with optimized physicochemical properties.

Main Methods:

  • A batch Bayesian Optimization strategy was employed.
  • A two-phase modeling approach navigated complex experimental spaces.
  • Five iterations with five experiments per batch were conducted.

Main Results:

  • Five high-performing blank microemulsions were identified.
  • Four formulations demonstrated physical stability for up to 30 days.
  • Drug-loaded microemulsions showed high drug loading, stability, and improved in-vitro permeability.

Conclusions:

  • Bayesian optimization significantly streamlines microemulsion formulation.
  • The developed method efficiently identifies stable and effective microemulsions.
  • Optimized microemulsions show promise for drug delivery applications.