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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jul 7, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Plant-Derived Polyphenols in the Fight against Colorectal Cancer.

Carely Arjona-Ruiz1, Eduardo E Valdez-Morales1,2, Raquel Guerrero-Alba1

  • 1Department of Physiology and Pharmacology, Center for Basic Sciences, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.

Anti-Cancer Agents in Medicinal Chemistry
|July 6, 2026
PubMed
Summary

Plant-derived polyphenols show promise as complementary treatments for colorectal cancer (CRC). While preclinical data is strong, more large-scale clinical trials are needed to confirm their safety and effectiveness in patients.

Keywords:
Colorectal cancerapoptosischemopreventioninflammationoxidative stresspolyphenols

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Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
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Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

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Last Updated: Jul 7, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Colorectal cancer (CRC) is a major global health concern, ranking as the third most common cancer and a leading cause of cancer-related death.
  • Current treatments for CRC, including surgery and chemotherapy, often face challenges such as limited efficacy, toxicity, and the development of drug resistance.
  • There is a critical need for complementary therapeutic strategies with improved safety profiles for CRC management.

Purpose of the Study:

  • To review and synthesize the existing evidence on the anticancer activities of plant-derived polyphenols in colorectal cancer.
  • To analyze the molecular mechanisms and chemopreventive potential of key polyphenols against CRC.
  • To evaluate the translational evidence from in vitro, in vivo, and clinical studies for polyphenol-based CRC therapies.

Main Methods:

  • Comprehensive literature review of in vitro, in vivo, and clinical studies investigating polyphenol effects on CRC.
  • Analysis of specific polyphenols including curcumin, resveratrol, quercetin, and epigallocatechin gallate (EGCG).
  • Examination of molecular pathways targeted by polyphenols, such as PI3K/AKT/mTOR, Wnt/β-catenin, STAT3, and MAPK/ERK.

Main Results:

  • In vitro studies confirm that polyphenols induce apoptosis and modulate key cancer pathways, oxidative stress, and inflammation.
  • In vivo studies demonstrate significant reductions in tumor volume, polyp formation, and aberrant crypt foci (ACF) with various polyphenols.
  • Clinical trials with curcumin show mixed results, with some indicating reduced ACF and improved inflammatory markers, while others show no significant clinical benefit.

Conclusions:

  • Preclinical data strongly support the chemopreventive role of plant-derived polyphenols in colorectal cancer.
  • Preliminary clinical evidence suggests therapeutic potential, but large-scale, well-controlled trials are essential to validate safety and efficacy.
  • Future research should focus on standardized formulations, optimized delivery, and rigorous clinical trials to integrate polyphenols into CRC treatment protocols.