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Updated: Jul 7, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Precise programmable tumor cell subpopulation sorting via an electromagnetic microfluidic platform.

Yuan Gao¹, Zhenwei Liang², Zeyu Wang¹

¹School of Mechanical-Electronic and Vehicle Engineering, Beijing University of Civil Engineering and Architecture, Beijing 102616, China. qinhua@bucea.edu.cn.

|July 6, 2026

Summary

This summary is machine-generated.

A novel electromagnetic microfluidic platform precisely sorts cells by protein expression, enabling dynamic control over capture thresholds and gentle cell release for advanced research.

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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

Area of Science:

Biotechnology
Microfluidics
Cell Sorting

Background:

High-throughput cell sorting is crucial for understanding diseases and finding treatments.
Conventional methods have limitations in isolating multiple subpopulations and preserving cell function.

Purpose of the Study:

To develop a programmable electromagnetic microfluidic platform for advanced cell sorting.
To overcome limitations of existing magnetic cell sorting techniques.

Main Methods:

Integrated an electromagnetic array with a microfluidic chip to generate tunable magnetic fields.
Utilized multi-channel currents for dynamic control of cell capture thresholds and release.
Employed semiconductor temperature control for gentle cell recovery.

Main Results:

Precisely classified cells into four subpopulations based on protein expression levels.
Demonstrated dynamic regulation of phenotypic expression profiles.
Achieved spatially localized enrichment of multiple cell types while preserving cellular functions.

Conclusions:

The developed platform offers a scalable and flexible solution for complex cell sorting tasks.
It has significant potential for tumor heterogeneity analysis, rare cell isolation, and drug evaluation.