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Related Experiment Video

Updated: Jul 7, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Published on: September 13, 2022

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual-Color Quantum Dot Probes for Precise Intraoperative

Dongdong Wu1, Chenxuan Yang1,2, Yuanbin Wu3

  • 1Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital Beijing, Beijing, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 6, 2026
PubMed
Summary

New dual-color probes accurately identify brain glioma boundaries and subtypes during surgery. This breakthrough enables faster, more precise tumor removal, improving personalized treatment strategies for patients.

Keywords:
dual‐color probegliomaperovskite nanocrystalprecision medicine

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Area of Science:

  • Oncology
  • Nanotechnology
  • Surgical Pathology

Background:

  • Brain gliomas present challenges for complete surgical resection due to variable growth and location.
  • Current intraoperative diagnostic methods lack the speed and accuracy to guide precise tumor removal.
  • Distinguishing glioma subtypes, such as IDH-mutant status, is crucial for treatment planning and margin delineation.

Purpose of the Study:

  • To develop and evaluate novel blue-green dual-color probes for simultaneous detection of glioma cells and IDH1-mutant status.
  • To enable rapid intraoperative pathological diagnosis for personalized glioma resection.
  • To establish a new strategy for precise glioma surgery guided by dual-probe detection.

Main Methods:

  • Conjugation of perovskite quantum dots with antibodies targeting glioma cells and the IDH1-mutation.
  • Application of the dual-color probes for in vitro pathological diagnosis on clinical frozen sections.
  • Evaluation of probe accuracy and detection time for intraoperative use.

Main Results:

  • The dual-color probes achieved 91% accuracy in combined detection within 30 minutes on 56 clinical frozen sections.
  • The glioma-targeting probe effectively identified tumor boundaries.
  • The IDH1-targeting probe successfully distinguished glioma subtypes, aiding in optimized margin delineation.

Conclusions:

  • The developed dual-color probes facilitate rapid intraoperative diagnosis of brain gliomas.
  • This technology enables precise identification of tumor margins and subtypes, crucial for personalized treatment.
  • The dual-target probes show significant potential to assist neurosurgeons in achieving more accurate glioma resections.