Related Experiment Video

Updated: Jul 7, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
05:57

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Oncohypertension: Unraveling the Link Between Cancer and Hypertension

Prakash Gudsoorkar1, Paul E Hanna2, Priti Meena3

  • 1Division of Nephrology, University of Cincinnati, Cincinncati, OH.

Advances in Kidney Disease and Health
|July 6, 2026
PubMed

Insights

Cancer treatments can cause hypertension due to distinct mechanisms, particularly involving vascular signaling pathways. This review integrates these insights with management strategies for oncology patients, highlighting the need for specialized care.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Cancer therapies improve survival but commonly cause hypertension.
  • Hypertension in cancer patients has unique mechanisms tied to treatments.
  • Targeted therapies, especially those inhibiting vascular signaling, are key drivers.

Purpose of the Study:

  • To review the mechanisms of cancer therapy-induced hypertension.
  • To integrate mechanistic insights with clinical management strategies for oncology.
  • To propose a framework for individualized hypertension management in cancer patients.

Main Methods:

  • Literature review focusing on vascular signaling pathways and targeted therapies.
  • Analysis of cancer biology and treatment factors contributing to hypertension.
  • Critical appraisal of current management strategies and identification of knowledge gaps.

Main Results:

  • Cancer treatments, particularly vascular endothelial growth factor (VEGF) inhibitors, frequently induce hypertension.
  • Distinct molecular pathways are implicated in therapy-related hypertension.
  • Current management strategies lack dedicated guidelines, necessitating tailored approaches.

Conclusions:

  • Cancer therapy-induced hypertension is a significant complication requiring specialized management.
  • Multidisciplinary, oncology-specific approaches are crucial for effective hypertension control.
  • Further research is needed to refine management strategies and address knowledge gaps.
Keywords:
Androgen deprivation therapy (ADT)Cardiovascular diseaseHypertensionTyrosine kinase inhibitor (TKI)Vascular endothelial growth factor inhibitor (VEGFi)

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...