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Updated: Jul 7, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Friend or foe? IFNλ drives fibrosis

Ivan Zanoni1

  • 1Harvard Medical School, Boston Children's Hospital , Boston, MA, USA.

The Journal of Experimental Medicine
|July 6, 2026
PubMed

Type III IFNs, or IFNλ, are pleiotropic immune mediators that mostly work at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang, and colleagues (https://doi.org/10.1084/jem.20251858) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal fibrosis.

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