Related Experiment Video

Updated: Jul 7, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Association between 24-h proteinuria and phenotypic age acceleration in adults with preserved kidney function: a

Yiqi Su^1,2,3,4, Fangfang Xiang^1,2,3, Yi Fang^5,6,7

¹Department of Nephrology, Zhongshan Hospital, Fudan University, No 180 Fenglin Rd, Shanghai, China.

International Urology and Nephrology

|July 6, 2026

Abstract

Purpose:

Phenotypic age acceleration (PhenoAgeAccel) captures biological aging beyond chronological age and has been associated with adverse health outcomes. Proteinuria is a common manifestation of kidney injury, yet its relationship with biological aging acceleration in individuals with preserved kidney function remains unclear.

Methods:

We conducted a cross-sectional study among adult nephrology outpatients with an estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m². Participants who completed a valid 24-h urinary protein excretion measurement were included. Phenotypic age was calculated using established clinical and laboratory parameters, and PhenoAgeAccel was defined as the difference between phenotypic age and chronological age. Associations between natural log-transformed 24-h urinary protein excretion and PhenoAgeAccel were evaluated using multivariable linear regression and spline-based analyses.

Results:

Among 253 adults with preserved eGFR (median age 44 years; median eGFR 93 mL/min/1.73 m²), Ln-transformed 24-h proteinuria (LnUPE) was positively correlated with PhenoAgeAccel (r = 0.488, 95% CI 0.388-0.576; P < 0.001). In multivariable analysis, LnUPE remained independently associated with PhenoAgeAccel (β = 3.55, 95% CI 2.74-4.37; P < 0.001). The association remained significant after excluding serum albumin from the PhenoAge algorithm (β = 1.78, 95% CI 1.01-2.54; P < 0.001) and persisted after further exclusion of both serum albumin and creatinine (β = 1.28, 95% CI 0.59-1.96; P < 0.001). No evidence of nonlinearity was observed (P for nonlinearity = 0.437). Mediation analysis suggested that total cholesterol, triglycerides, and low-density lipoprotein cholesterol statistically accounted for 30.0%, 12.6%, and 21.8% of the observed association, respectively (all P < 0.001), while the direct association remained significant.

Conclusions:

Elevated proteinuria is associated with accelerated biological aging in adults with preserved kidney function, highlighting a potential link between early kidney injury and accelerated biological aging.

Keywords:

Biological aging Phenotypic age acceleration Preserved kidney function Proteinuria

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

Serum Studies: Renal Function Tests

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.

Articles linked to this work by shared authors, journal, and citation graph.

O-Glycosylation of E-Cadherin Induced by Endoplasmic Reticulum Stress Negatively Regulates Cell Polarity and Proliferation in Acute Kidney Injury.

Journal of biochemical and molecular toxicology·2026

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis.

Molecular biomedicine·2026

Indoxyl sulfate exacerbates chronic inflammation and susceptibility to severe infection via modulating T-cell CD73/adenosine signaling in chronic kidney disease.

Renal failure·2026

Association between long-term exposure to particulate matter 2.5 and the risk of rapid renal function decline: a prospective study from CHARLS.

Clinical kidney journal·2026

Capability of multiparametric MRI to detect diabetic nephropathy in high-risk patients with type 2 diabetes: a prospective preliminary study.

BMC medical imaging·2026

Risk of acute kidney injury in patients on concomitant vancomycin and piperacillin-tazobactam compared to vancomycin and other beta-lactam agents: a large multicenter retrospective cohort study from China.

Microbiology spectrum·2026

See all related articles