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A Single-Institution Comparative Analysis of Bracketed Localization for Partial Mastectomy Using Traditional Wire and
Olivia W Galloway1, Ashley Wilbers2, Omolade O Sogade3
1Division of Surgical Oncology, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. olivia.w.galloway@gmail.com.
Annals of Surgical Oncology
|July 6, 2026
Summary
Wireless and wire bracketed localization for breast cancer offer similar outcomes for margin status. Factors like disease size and imaging characteristics influence close or positive margins, guiding surgical decisions.
Area of Science:
- Oncology
- Radiology
- Surgical Oncology
Background:
- Wire and wireless seeds are used for breast lesion localization to avoid mastectomy.
- Direct comparisons between wire and wireless bracketed localization are limited.
- This study compares these two localization methods and identifies factors affecting margin status.
Purpose of the Study:
- To compare the effectiveness of wireless versus wire bracketed localization for breast malignancy.
- To identify factors associated with positive or close surgical margins in bracketed localization.
Main Methods:
- Retrospective review of 240 patients undergoing bracketed localization for malignancy (2019-2024).
- Exclusion of patients with benign pathology or those undergoing oncoplastic surgery.
- Comparison of demographics, radiographic features, pathology, and margin status between localization groups.
Main Results:
- No significant differences in final margin status or need for additional surgery between wire and wireless localization.
- 66 patients (28.5% wire, 24.6% wireless) had close or positive margins.
- Factors associated with close/positive margins included disease size, grade, biopsy findings, pathology, and imaging characteristics.
Conclusions:
- Wireless and wire bracketed localization demonstrate comparable final margin status.
- Identified factors associated with positive/close margins can help predict need for wider resection or re-operation.
