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Multiparametric analysis using MRI after preoperative embolization in meningioma: a preliminary study.
Ling Li1, Naoki Ohno1, Mitsuhito Mase2
1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
Radiological Physics and Technology
|July 6, 2026
Summary
Preoperative embolization of meningiomas causes early ischemic changes within the tumor, shown by reduced volume and perfusion. Peritumoral edema remains unaffected in the early postembolization period.
Area of Science:
- Neuroradiology
- Oncology
- Medical Imaging
Background:
- Quantitative assessment of early changes in meningiomas post-embolization is limited.
- Understanding these early changes is crucial for evaluating treatment effectiveness.
Purpose of the Study:
- To investigate early structural and perfusion changes in supratentorial meningiomas after preoperative embolization using multiparametric MRI.
- To differentiate changes within the intratumoral region from peritumoral edema.
Main Methods:
- Seven patients with supratentorial meningiomas underwent MRI before and 1-2 days after embolization.
- Multiparametric MRI assessed intratumoral and peritumoral edema volumes, quantitative T2, and intravoxel incoherent motion (IVIM) parameters (D, f, D*, fD*, ΔD).
Main Results:
- Significant reductions in intratumoral volume, quantitative T2, and perfusion-related IVIM parameters (f, D*, fD*) were observed post-embolization.
- The true diffusion coefficient (D) and dynamic parameter (ΔD) showed no significant changes.
- Peritumoral edema parameters remained stable, indicating limited early effects beyond the tumor.
Conclusions:
- Preoperative embolization leads to early ischemia within the intratumoral region of meningiomas.
- Early MRI changes reflect reduced viable tumor volume and perfusion, primarily affecting the tumor itself, not the surrounding edema.
