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Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Related Experiment Video

Updated: Jul 7, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

Public Interest in Hyperpigmentation: Insights From a Google Trends Analysis.

Grace Ugwueke, Nada Elbuluk

Journal of Drugs in Dermatology : JDD

|July 6, 2026

Summary

Public interest in hyperpigmentation and other pigmentary disorders has significantly increased globally over the past two decades. Google Trends data reveals growing consumer awareness and information-seeking behaviors related to these skin conditions.

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Quantification of Hypopigmentation Activity In Vitro

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Published on: May 23, 2025

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

Dermatology
Public Health
Digital Epidemiology

Background:

Pigmentary disorders, especially hyperpigmentation, disproportionately impact individuals with skin of color, causing significant psychosocial distress.
Real-time data on public awareness and interest in these prevalent conditions are limited.
Digital tools like Google Trends offer novel methods for assessing public interest in dermatologic conditions.

Purpose of the Study:

To evaluate public interest trends in hyperpigmentation and related terms using Google Trends.
To analyze temporal, seasonal, and geographical patterns of public search interest in pigmentary disorders.
To understand consumer awareness and information-seeking behaviors regarding skin pigmentation.

Main Methods:

Google Trends data from 2004 to 2025 were analyzed for terms including "hyperpigmentation", "pigmentation", "skin brightening", "brown spots", and "dark spot treatment".
Relative Search Volume (RSV) was used to assess normalized search popularity in the US and globally.
Temporal trends, seasonal variations, and geographical distributions of search interest were examined.

Main Results:

A sustained global and domestic increase in search interest for pigmentary disorder terms was observed over time.
"Pigmentation" and "hyperpigmentation" showed the highest search interest, with a notable spike in "hyperpigmentation" in early 2025.
Seasonal peaks for "brown spots" occurred in summer, with highest US interest in southern states. Ghana, Nigeria, and Mauritius showed high global interest.

Conclusions:

Public interest in pigmentary disorders has markedly increased over the last 20 years.
Google Trends effectively reveals consumer awareness and information-seeking patterns related to skin pigmentation.
Findings can guide public health initiatives and culturally sensitive interventions for affected populations.