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Updated: Jul 7, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Marked Response to Immunochemotherapy in Airway Mucosal Recurrence of Lung Squamous Cell Carcinoma
Zijian Li1, Chudong Wang1, YenZhir Tay2
1Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.
Objectives:
Airway mucosal recurrence after complete resection of primary lung cancer is rare and lacks standard treatment. We aim to report a marked response to immunochemotherapy in a patient with multifocal airway mucosal recurrence of lung squamous cell carcinoma.
Case Description:
A 50-year-old male patient presented with an irritative cough 2 years after right upper sleeve lobectomy for lung squamous cell carcinoma (SCC) (pT1bN0M0). Computed tomography and bronchoscopy revealed multiple recurrent polypoidal lesions in the trachea, with biopsy confirming recurrent SCC. After restaging and multidisciplinary evaluation, the patient was offered immunochemotherapy. The recurrent mucosal lesions exhibited a favourable response to the combination of a PD-1 inhibitor and chemotherapy.
Conclusions:
This case suggests a potentially effective strategy for high-risk patients with airway mucosal recurrence of lung squamous cell carcinoma.
