Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The urine metabolomic signature of distal diuretics and diuretic-induced hyponatremia in patients with chronic kidney disease.

American journal of physiology. Renal physiology·2026
Same author

Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.

Nature communications·2026
Same author

Extracellular Vesicles Facilitate the Crosstalk Between High Glucose-Stimulated Mesangial Cells and Healthy Podocytes to Mediate Injury Responses.

International journal of molecular sciences·2026
Same author

JAK3 Staining and CD68+ Macrophage Counts Are Increased in Patients with IgA Nephropathy.

Diagnostics (Basel, Switzerland)·2026
Same author

Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis.

International journal of molecular sciences·2025
Same author

Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment.

Cell biochemistry and function·2025

Related Experiment Video

Updated: Jul 8, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Kidney Health in a Changing Climate: Emerging Disease Patterns and Driving Mechanisms.

Suemy Melim Yamada1, Marcella Cipelli1, Pablo Shimaoka Chagas1

  • 1Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.

Kidney360
|July 6, 2026
PubMed
Summary

Climate change is increasing kidney disease globally. Rising temperatures and heat stress, especially during manual labor, contribute to chronic kidney disease (CKD) and acute kidney injury, disproportionately affecting vulnerable populations.

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jul 8, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Environmental Health
  • Nephrology
  • Climate Science

Background:

  • Chronic kidney disease (CKD) affects 850 million worldwide, with increasing incidence linked to climate change.
  • High-temperature regions often coincide with socio-economic vulnerability and rising temperatures.
  • Heat exposure, impaired heat dissipation, and environmental stressors elevate acute kidney injury risk and CKD progression.

Purpose of the Study:

  • To integrate population data and biological insights on climate-driven kidney disease.
  • To examine temperature trends, identify high-burden countries, and analyze epidemiological indicators.
  • To elucidate molecular pathways linking heat stress to kidney damage and explore evolutionary adaptation limits.

Main Methods:

  • Analysis of historical and current temperature data.
  • Review of epidemiological data on kidney disease incidence and mortality.
  • Integration of mechanistic biological insights into heat-sensitive molecular pathways.

Main Results:

  • A 30% increase in kidney disease morbidity observed in high-heat regions.
  • Identified heat-associated CKD epidemics in Central America, Mexico, India, and Sri Lanka.
  • Linked heat stress to dehydration, mitochondrial dysfunction, tubular injury, inflammation, and uric acid stone formation.

Conclusions:

  • Climate change, particularly heat stress and dehydration, significantly contributes to kidney disease.
  • Vulnerable populations face a disproportionate burden of heat-associated kidney disease.
  • Understanding these multilevel interactions is vital for prevention, diagnosis, and policy development to mitigate global kidney disease rise.