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Related Experiment Video

Updated: Jul 8, 2026

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
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Consensus definition for developmental regression during childhood.

Gauravi Gawade1, Ellaina P Andersson2, Ava Nielsen3

  • 1Eastern Health, Melbourne, Victoria, Australia.

Developmental Medicine and Child Neurology
|July 6, 2026
PubMed
Summary
This summary is machine-generated.

A new definition for developmental regression was established, involving skill loss in childhood lasting at least four weeks across six key developmental domains. This aims to standardize care and improve understanding of its causes.

Keywords:
Loss of skillschildrendevelopmental disabilitiesdevelopmental regressionneurodevelopmental disorders

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Area of Science:

  • Pediatric Neurology
  • Developmental Psychology
  • Clinical Genetics

Background:

  • Developmental regression is a complex symptom observed in various pediatric conditions, including autism, Rett syndrome, and Landau-Kleffner syndrome.
  • Existing definitions are inconsistent, hindering accurate diagnosis, prevalence studies, and standardized patient care.

Purpose of the Study:

  • To establish a consensus-based definition of developmental regression.
  • To standardize the approach for identifying and investigating developmental regression.
  • To improve the consistency of care for children experiencing developmental regression.

Main Methods:

  • An interdisciplinary panel of clinicians reviewed existing literature on developmental regression definitions.
  • A two-round Delphi survey was employed to gather expert opinions on essential definitional components.
  • Consensus was defined as agreement among at least 70% of participating clinicians.

Main Results:

  • A consensus definition for developmental regression was achieved.
  • Developmental regression is defined as the loss of skills during childhood, persisting for a minimum of four weeks.
  • This skill loss must impact at least one of six developmental domains: verbal communication, nonverbal communication, functional motor skills, cognition, social skills, or self-help skills.

Conclusions:

  • A working definition for developmental regression has been proposed.
  • This definition is intended to be refined through clinical application and further research.
  • The proposed definition aims to enhance clinical utility and research consistency in the field of developmental regression.