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Updated: Jul 8, 2026
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Published on: March 11, 2014
Human Papillomavirus Infection in Patients With VaIN and Vaginal Cancer: A Retrospective Cross-Sectional Study
Chenyao Guo1, Zhongyue Yan2, Jing Li1
1Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University.
Journal of Lower Genital Tract Disease
|July 6, 2026
Summary
Human papillomavirus (HPV) types 16, 52, 58, 53, and 18 are common in vaginal intraepithelial neoplasia (VaIN) and vaginal cancer. HPV testing aids in detecting vaginal lesions and HPV vaccination may reduce their incidence.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Vaginal cancer is rare, with limited research.
- Human papillomavirus (HPV) is implicated in various anogenital cancers.
- Understanding HPV's role in vaginal lesions is crucial for diagnosis and prevention.
Purpose of the Study:
- To investigate the characteristics of HPV infection in patients with vaginal intraepithelial neoplasia (VaIN) and vaginal cancer.
- To analyze the distribution and prevalence of specific HPV genotypes in these conditions.
Main Methods:
- Retrospective analysis of 5,180 patients undergoing colposcopy and biopsy for abnormal cytology or positive HPV tests.
- Histological diagnosis of benign vaginitis, VaIN, or vaginal cancer.
- Collection of clinical data and HPV DNA testing.
Main Results:
- HPV infection was detected in 4,548 patients.
- High HPV prevalence in VaIN2/3 (95.5%) and vaginal squamous cell carcinoma (VaSCC) (86.0%).
- HPV types 16, 52, 58, 53, and 18 were predominant; HPV18 was most common in vaginal adenocarcinoma.
Conclusions:
- HPV genotypes 16, 52, 58, 53, and 18 are prevalent in VaIN and vaginal cancer in Shanxi, China.
- HPV testing is beneficial for detecting vaginal lesions during cervical cancer screening.
- HPV vaccination could potentially decrease the incidence of these lesions.
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