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Interfacial structure-modified nanozyme drives single-receptor-single-reaction-unit multichannel sensor array for
Jin Liu1, Jiyue Zhao1, Hongxiang Chen1
1School of Chemistry and Chemical Engineering, Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology, Wuhan, 430081, China.
Biosensors & Bioelectronics
|July 6, 2026
Summary
Researchers developed novel cobalt oxide-bismuth (Co3O4@Bi) nanozymes for a simplified multichannel sensor array. This new design enhances pesticide detection accuracy and selectivity, overcoming the complexity of traditional sensor arrays.
Area of Science:
- Materials Science
- Nanotechnology
- Analytical Chemistry
Background:
- Sensor arrays are effective for detecting complex analytes but often require multiple receptors and sensing units, increasing complexity.
- Developing simplified sensor arrays with high selectivity and sensitivity remains a challenge in analytical chemistry.
Purpose of the Study:
- To design and synthesize Co3O4@Bi nanozymes with a unique Co-O-Bi interfacial structure for a single-receptor, single-reaction-unit multichannel sensor array.
- To enhance the catalytic activity and selectivity of nanozymes for improved analytical performance.
- To address the limitations of traditional sensor arrays by reducing the number of required receptors and sensing units.
Main Methods:
- Synthesis of Co3O4@Bi nanozymes featuring a Co-O-Bi interfacial structure.
- Characterization of the nanozymes' structure and catalytic properties, including peroxidase-like and oxidase-like activities.
- Development of a multichannel sensor array using Co3O4@Bi nanozymes as the single receptor and a chromogenic reaction as the single unit.
- Evaluation of the sensor array's ability to discriminate and identify pesticides based on their inhibitory effects on nanozyme activity.
Main Results:
- The Co3O4@Bi nanozymes exhibited a 3.6-fold enhancement in peroxidase-like activity compared to Co3O4 nanozymes, attributed to the Co-O-Bi interfacial structure facilitating electron transfer.
- The developed sensor array successfully achieved 100% discrimination of five different pesticides, even in combined use, by utilizing three distinct characteristic peaks as multiple signal channels.
- The colorimetric sensor array demonstrated high selectivity and anti-interference capability in accurately identifying target pesticides.
Conclusions:
- The Co-O-Bi interfacial structure in Co3O4@Bi nanozymes significantly enhances catalytic activity and selectivity, offering a new strategy for nanozyme design.
- The single-receptor, single-reaction-unit multichannel sensor array effectively simplifies detection complexity while maintaining high accuracy and discrimination capabilities for pesticides.
- This work provides a promising approach for developing advanced sensor arrays that overcome the limitations of traditional multi-component systems.
