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An injectable PLCL/CaHA microsphere composite gel for enhanced skin regeneration.

Xiaowei Wang¹, Xiaoli Chen¹, Ruofan Gao²

¹NMPA Key Laboratory for Dental Materials National Engineering, Laboratory for Digital and Material Technology of Stomatology, Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

Biomaterials Advances

|July 6, 2026

Summary

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This study introduces a novel injectable gel composite for enhanced skin regeneration. The developed material promotes fibroblast activity, accelerates wound healing, and improves tissue repair, offering a promising solution for soft tissue injuries.

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Efficient skin regeneration is hindered by complex biological factors and limitations of current wound dressings.
Existing dressings often exhibit biological inertness and insufficient biodegradability, impeding effective tissue repair.

Purpose of the Study:

To develop an injectable composite gel for enhanced skin regeneration.
To evaluate the efficacy of a novel PLCL/CaHA composite within a CMC/mannitol hydrogel carrier for wound healing.

Main Methods:

Fabrication of an injectable composite gel with PLCL/CaHA microspheres in a CMC/mannitol hydrogel.
Structural characterization of the composite material.
In vitro assessment of fibroblast migration, gene expression, and proliferation.

Keywords:

Composite microspheres gel Injectable gel PLCL/CaHA composite Skin regeneration Wound healing

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In vivo evaluation in a murine full-thickness wound model, assessing wound closure, angiogenesis, and macrophage polarization.

Main Results:

The PLCL/CaHA composite exhibited a uniform dispersion of CaHA nanoparticles within PLCL microspheres.
In vitro studies showed enhanced fibroblast migration, ECM gene upregulation, and proliferation.
In vivo, the composite accelerated wound closure, improved angiogenesis and vessel maturation, and promoted M2 macrophage polarization.

Conclusions:

The structurally engineered PLCL/CaHA composite gel creates a favorable microenvironment for tissue regeneration.
This novel composite platform demonstrates significant potential for effective soft tissue repair and wound healing.