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Published on: January 9, 2026
Gut Microbiome-Associated Thrombosis: Approaching Validation?
Konstantina Tsante1, Eleni Petrou1, Stavros Tsalas1
1Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Laboratory of Haematology and Blood Bank Unit, Greece, Athens.
Seminars in Thrombosis and Hemostasis
|July 6, 2026
Summary
The gut microbiome influences thrombotic diseases via immunometabolic pathways. Emerging evidence links gut dysbiosis to venous thromboembolism, highlighting a potential role in thrombosis development.
Area of Science:
- Microbiome research
- Immunometabolism
- Cardiovascular science
Background:
- The gut microbiome plays a role in modulating thrombotic disease through complex pathways.
- Microbiome-derived metabolites are linked to platelet activation, endothelial injury, and cardiovascular outcomes.
- While the link to arterial thrombosis is clearer, gut dysbiosis is increasingly recognized as a factor in venous thromboembolism.
Purpose of the Study:
- To review the current evidence on the gut microbiome's role in thrombotic disease.
- To explore the immunometabolic and interorgan pathways involved.
- To assess the contribution of gut dysbiosis to venous thromboembolism pathogenesis.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of studies investigating microbiome-metabolite interactions.
- Evaluation of evidence linking gut dysbiosis to arterial and venous thrombosis.
Main Results:
- Gut microbiome metabolites are associated with key thrombotic processes like platelet activation and endothelial injury.
- Accumulating data suggest gut dysbiosis is an underrecognized contributor to venous thromboembolism.
- A biologically plausible association between the gut microbiome and thrombosis is supported by current evidence.
Conclusions:
- The gut microbiome is an important modulator of thrombotic disease.
- Further research is necessary to elucidate the precise mechanisms and clinical significance of the gut microbiome's role in thrombosis.
- Understanding these pathways could lead to novel therapeutic strategies for thrombotic disorders.
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