Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Organization of the Brain01:31

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perceived stress of mental demands at work, objective stress and resilience - an analysis of the LIFE-Adult-study.

Journal of occupational medicine and toxicology (London, England)·2023
Same author

Neurocognitive predictors of food memory in healthy adults - A preregistered analysis.

Neurobiology of learning and memory·2023
Same author

Influence of noninvasive brain stimulation on connectivity and local activation: a combined tDCS and fMRI study.

European archives of psychiatry and clinical neuroscience·2023
Same author

Leptin, but not ghrelin, is associated with food addiction scores in a population-based subject sample.

Frontiers in psychiatry·2023
Same author

Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling.

Nature communications·2023
Same author

Modeling venous bias in resting state functional MRI metrics.

Human brain mapping·2023

Related Experiment Video

Updated: Jul 8, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Mapping the Heart-Brain Continuum beyond Heart Failure: Why Neurology Matters.

Xia Zhang1, Khosrov A Grigoryan2, Nico Scherf3

  • 1Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany zhangx@cbs.mpg.de Karstenm@cbs.mpg.de.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 6, 2026
PubMed
Summary

Cardiac dysfunction predicts future brain gray matter damage, impacting memory. This microstructural brain integrity is key for preventing cognitive decline in heart patients.

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
05:23

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Related Experiment Videos

Last Updated: Jul 8, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
05:23

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Area of Science:

  • Cardiology
  • Neurology
  • Neuroimaging

Background:

  • Cardiac dysfunction is linked to cognitive impairment.
  • Early detection of brain changes associated with cardiac issues is crucial.

Purpose of the Study:

  • To determine if cardiac dysfunction predicts gray matter microstructural integrity.
  • To investigate if brain integrity mediates the link between cardiac health and cognition.

Main Methods:

  • Prospective observational cohort study of 73 patients.
  • Baseline cardiac assessments (ejection fraction, natriuretic peptide) and diffusion-weighted MRI.
  • Cognitive testing after 3.5 years with mediation analysis.

Main Results:

  • Lower ejection fraction predicted future gray matter mean diffusivity, even in non-heart failure patients.
  • Higher natriuretic peptide predicted microstructural damage in heart failure patients.
  • Increased diffusivity in Alzheimer's-vulnerable regions mediated memory decline.

Conclusions:

  • Cardiac dysfunction is linked to progressive brain microstructural damage.
  • Brain microstructural integrity mediates the association between cardiac health and memory.
  • Preserving brain integrity is a critical intervention target for cognitive health.