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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: Jul 8, 2026

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA
06:40

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA

Published on: June 7, 2022

Sequencing parasite genomes, one worm at a time.

Lewis Stevens1, Stephen R Doyle1

  • 1Wellcome Sanger Institute, Hinxton, England, UK.

Trends in Parasitology
|July 6, 2026
PubMed
Summary

Genomic sequencing of parasitic worms is advancing rapidly. New methods enable high-quality genomes, improving our understanding of these diverse organisms and their host interactions.

Area of Science:

  • Parasitology
  • Genomics
  • Molecular Biology

Background:

  • Parasitic worms, including nematodes and platyhelminths, are taxonomically diverse.
  • Understanding their genomes is crucial for comprehending host adaptation and persistence.
  • Genomic studies of parasitic worms face challenges like limited sample access and high genetic diversity.

Purpose of the Study:

  • To highlight the importance of high-quality reference genomes for parasitic worms.
  • To advocate for the adoption of advanced sequencing techniques in parasitic worm research.
  • To emphasize the potential of pangenomes in capturing within-species variation.

Main Methods:

  • Utilizing advances in whole-genome amplification.
  • Employing long-read sequencing technologies.
Keywords:
genome assemblygenomicspangenomesparasitic wormsreference genomes

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  • Generating high-quality genomes from individual parasitic worms.

    • Main Results:

    • Enabling the generation of high-quality genomes from individual worms.
    • Facilitating a rapid increase in the quality and diversity of parasitic worm reference genomes.
    • Paving the way for pangenomes that capture comprehensive within-species variation.

    Conclusions:

    • Advanced sequencing approaches are overcoming previous limitations in parasitic worm genomics.
    • These technological advancements will significantly enhance our understanding of parasitic worm biology.
    • The transition to pangenomes promises a more complete view of parasitic worm diversity and adaptation.