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Breast cancer and coronary artery disease: insights from a national inpatient sample analysis

Omar Obeidat1, Moh'd Daise1, Qusai Alqudah1

  • 1Graduate Medical Education/HCA Florida North Florida Hospital, Internal Medicine Residency Program, University of Central Florida College of Medicine, Gainesville, FL, USA.

Future Cardiology
|July 6, 2026
PubMed

Insights

Women with breast cancer (BC) did not have higher odds of coronary artery disease (CAD)-related hospitalizations. This study found no increased risk of CAD hospitalization in breast cancer patients, suggesting a need for further research into cardiovascular health in survivors.

Area of Science:

  • Cardiology
  • Oncology
  • Epidemiology

Background:

  • The link between breast cancer (BC) and coronary artery disease (CAD) is significant due to shared risk factors and cancer treatment's potential cardiotoxicity.
  • A growing population of breast cancer survivors necessitates understanding their cardiovascular health.
  • Investigating the association between BC and CAD is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine if women with active or prior breast cancer have increased odds of CAD-related hospitalization.
  • To utilize a nationally representative inpatient database for robust analysis.
  • To compare hospitalization rates between breast cancer patients and a control group.

Main Methods:

  • Retrospective analysis of the 2016-2019 National Inpatient Sample.
  • Comparison of adult women with and without breast cancer, including over 2.9 million weighted hospitalizations.
  • Propensity score matching and multivariable logistic regression to control for demographic and clinical factors.

Main Results:

  • Breast cancer was not associated with increased odds of CAD-related hospitalization.
  • The unmatched cohort showed lower odds of CAD hospitalization in breast cancer patients (OR 0.84).
  • After matching, the association attenuated but remained non-significant (OR 0.99), with lower odds for STEMI and NSTEMI.

Conclusions:

  • Breast cancer is not associated with an increased risk of coronary artery disease hospitalization.
  • Findings suggest that breast cancer patients may not have a higher burden of CAD-related hospital admissions.
  • Further research is warranted to explore the nuances of cardiovascular outcomes in breast cancer survivors.
Abstract

Keywords:
Breast cancercancer survivorshipcardiovascular riskcoronary artery diseasepropensity score matching

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