Calcium Hydroxylapatite Combined with CO₂ Ablative Fractional Laser for Atrophic Acne Scars: A Randomized Controlled...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Laser Therapy

Background:

• Atrophic acne scars present a significant cosmetic concern.
• Investigating novel treatment combinations is crucial for improving patient outcomes.

Purpose of the Study:

• To evaluate the efficacy and safety of calcium hydroxylapatite (CaHA) filler injections combined with CO2 ablative fractional laser (AFL) for treating atrophic acne scars.
• To compare this combination therapy against AFL monotherapy.

Main Methods:

• A prospective, randomized controlled study involving 160 participants.
• Group A received two sessions of CaHA (1-month interval) after AFL, while Group B received AFL monotherapy.
• Efficacy was assessed using standardized photographic images and scar rating scales; adverse events were documented.

Main Results:

• The combination therapy (Group A) showed significantly greater improvement in atrophic acne scars compared to AFL monotherapy (Group B).
• Both treatment modalities were effective across all scar subtypes, with comparable results for boxcar and rolling scars.
• While mild adverse events occurred in both groups, the combination therapy demonstrated significantly shorter healing times for long-term post-inflammatory erythema and hyperpigmentation.

Conclusions:

• The combination of CaHA filler injections and AFL is an effective and safe treatment for atrophic acne scars.
• This approach is particularly beneficial for boxcar and rolling acne scar subtypes.
• The combined therapy accelerates healing and reduces the duration of common post-treatment side effects.