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Letter: Interpretation of Cognitive and Clinical Outcomes in the Randomised Trial of Rifaximin for Covert Hepatic

Glen Saward1, Sumaya Al-Ukaidey1

  • 1Department of Gastroenterology, Barwon Health, Geelong, Australia.

Alimentary Pharmacology & Therapeutics
|July 6, 2026
PubMed
Abstract

No abstract available in PubMed .

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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...