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Published on: October 19, 2014
Self-disgust and its associated factors among patients with malignant lymphoma: a latent profile analysis
Fang Liao1, Ya-Ling Chen1, Shan-Shan Zhang1
1Department of Hematology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Purpose:
To evaluate the severity and independent predictors of self-disgust in patients with malignant lymphoma, and to develop and internally validate a clinical nomogram for personalized risk prediction.
Methods:
This cross-sectional study included 200 patients with malignant lymphoma from two tertiary hospitals in Chengdu, China (January-July 2025). Self-disgust was assessed using the Questionnaire for the Assessment of Self-Disgust (QASD). Predictors were identified through a combination of LASSO regression and multivariable logistic regression analysis. A predictive nomogram was subsequently constructed and internally validated using bootstrap resampling (1,000 iterations). Model performance was evaluated based on discrimination (AUC), calibration plots, and decision curve analysis (DCA).
Results:
The median QASD score was 30.0 (interquartile range: 24.0-40.0). Multivariable logistic regression identified five independent predictors of the high self-disgust profile. Risk factors included worker status (OR = 4.16, 95% CI: 1.51-11.93, P = 0.006), greater fear of the future (OR = 1.98, 95% CI: 1.29-3.14, P = 0.002), advanced Ann Arbor stage (OR = 1.56, 95% CI: 1.17-2.11, P = 0.003), and negative coping style (OR = 1.16, 95% CI: 1.07-1.27, P < 0.001). Conversely, psychological resilience served as a significant protective factor (OR = 0.91, 95% CI: 0.87-0.96, P = 0.001). The final predictive model demonstrated satisfactory discrimination (AUC = 0.808) and explanatory power (Nagelkerke R2 = 0.341). The Hosmer-Lemeshow test (P = 0.645) and calibration curves (mean absolute error = 0.013) indicated high agreement between predicted and observed probabilities. Furthermore, decision curve analysis (DCA) confirmed the clinical utility of the nomogram.
Conclusion:
Self-disgust is a prevalent psychosocial burden in lymphoma survivors, primarily associated with existential fear, occupational role disruption, and maladaptive coping. The developed exploratory nomogram provides oncology nurses with a reliable, evidence-based tool for early risk stratification, facilitating targeted, proactive psychosocial interventions to preserve patient dignity.
