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Updated: Jul 8, 2026
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Selpercatinib-induced Redifferentiation and Enhanced Radioiodine Uptake in Radioiodine-refractory Thyroid Cancer: A
Zizhen Zhang1, Jinxin Zhou, Yang Liu
1Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract:
A 32-year-old woman with metastatic papillary thyroid carcinoma, confirmed to harbor an NCOA4-RET fusion and progressing to radioiodine-refractory status, was initiated on selpercatinib. Following 10 months of treatment, serial thyroglobulin (Tg) measurements and post-therapeutic 131I scans after recombinant human TSH stimulation were performed. The scans demonstrated restored diffuse radioiodine uptake in previously refractory lung metastases, accompanied by a significant decline in Tg levels. This case illustrates that selpercatinib can induce effective redifferentiation in RET-altered radioiodine-refractory thyroid cancer, enabling successful radioiodine therapy.
