Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hepatic Metastasis From Duodenal Ampullary Carcinoma With Intense FAP Activity But Without FDG Uptake.

Clinical nuclear medicine·2025

Same author

Intrathoracic Involvements of Immunoglobulin G4-Related Sclerosing Disease.

Medicine·2015

Same author

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.

European journal of pharmacology·2015

Same author

Health risk assessment of migrant workers' exposure to polychlorinated biphenyls in air and dust in an e-waste recycling area in China: Indication for a new wealth gap in environmental rights.

Environment international·2015

Same author

Direct Observation of the Biaxial Stress Effect on Efficiency Droop in GaN-based Light-emitting Diode under Electrical Injection.

Scientific reports·2015

Same author

Spectra Library: An Assumption-Free In Situ Method to Access the Kinetics of Catechols Binding to Colloidal ZnO Quantum Dots.

Angewandte Chemie (International ed. in English)·2015

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Analysis of ¹⁸FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Lupus Lymphadenitis With Intense Pentixafor Avidity But Absent FDG Uptake.

Runze Duan^1,2, Tian Yue Li², Wei Lin³

¹Hebei Medical University.

Clinical Nuclear Medicine

|July 7, 2026

Summary

This summary is machine-generated.

Gallium-68 Pentixafor PET/CT effectively identified lupus lymphadenitis in a patient with fever and pancytopenia, unlike standard FDG PET/CT. This imaging approach aids in diagnosing this rare manifestation of systemic lupus erythematosus.

Keywords:

18F-FDG 68Ga-Pentixafor PET/CT lupus lymphadenitis systemic lupus erythematosus

Related Experiment Videos

Last Updated: Jul 8, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Analysis of ¹⁸FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

Nuclear Medicine
Immunology
Rheumatology

Background:

Lupus lymphadenitis is a rare manifestation of systemic lupus erythematosus (SLE).
Diagnosis can be challenging due to non-specific symptoms like fever and lymphadenopathy.
Standard imaging modalities may not always differentiate it from other conditions.

Purpose of the Study:

To evaluate the utility of 68Ga-Pentixafor PET/CT in diagnosing lupus lymphadenitis.
To compare 68Ga-Pentixafor PET/CT with 18F-FDG PET/CT in a patient with suspected lupus lymphadenitis.

Main Methods:

A patient with unexplained fever, pancytopenia, and lymphadenopathy underwent both 18F-FDG PET/CT and 68Ga-Pentixafor PET/CT.
Lymph node biopsy and serological tests for autoimmune markers were performed.
Treatment response was assessed after initiating SLE therapy.

Main Results:

18F-FDG PET/CT showed negative findings for lymph node lesions.
68Ga-Pentixafor PET/CT demonstrated high tracer uptake in the enlarged lymph nodes.
Biopsy confirmed reactive lymphoid hyperplasia, and elevated autoantibodies (anti-ds-DNA, anti-SS-A, anti-RNP) supported the SLE diagnosis.
Antisystemic lupus erythematosus therapy led to significant regression of lymphadenopathy.

Conclusions:

68Ga-Pentixafor PET/CT can be a valuable tool for detecting lupus lymphadenitis when conventional imaging is inconclusive.
This specific radiotracer may offer superior sensitivity for identifying affected lymph nodes in SLE patients.
Early diagnosis and appropriate treatment of lupus lymphadenitis are crucial for patient outcomes.