Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Palliative care for patients with haematologic malignancies: challenges and opportunities.

Annals of palliative medicine·2026
Same author

Palliative care for patients with haematologic malignancies: challenges and opportunities.

Annals of palliative medicine·2026
Same author

Models, outcomes, barriers, and facilitators of supportive care in cancer: a scoping review.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Estimating post-operative complication rates in patients with primary brain tumours from routine administrative data: A national cohort study.

PloS one·2026
Same author

Social determinants of health in studies using PROMs to assess toxicities associated with immune checkpoint inhibitor treatment: a systematic review.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Recent advances in autoantibody-mediated pain.

Current opinion in supportive and palliative care·2026
Same journal

Functional and molecular diversity of human C-fibers in pain modulation.

Current opinion in supportive and palliative care·2026
Same journal

The multidimensional impact of malnutrition in incurable cancer.

Current opinion in supportive and palliative care·2026
Same journal

The forgotten burden: nutrition impact symptoms in colorectal cancer survivorship.

Current opinion in supportive and palliative care·2026
Same journal

Cortical and brainstem mechanisms of pain: linking defensive responses, descending modulation, and affective-sensory integration.

Current opinion in supportive and palliative care·2026
Same journal

Comparison of the EORTC QLQ-EN24, FACT-En, and FEnSI-23 for assessing quality of life in endometrial cancer: a systematic review.

Current opinion in supportive and palliative care·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Practical prescribing in cancer cachexia.

Dan Monnery1,2, Joanne Collins3, Joanne Droney4

  • 1Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.

Current Opinion in Supportive and Palliative Care
|July 7, 2026
PubMed
Summary
This summary is machine-generated.

Olanzapine shows promise for managing cancer cachexia by improving appetite and weight, and reducing chemotherapy side effects. It is recommended over older treatments like steroids for supportive oncology care.

Keywords:
cancer cachexianutritionolanzapinepharmacotherapy

Related Experiment Videos

Last Updated: Jul 8, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Oncology
  • Pharmacology
  • Palliative Care

Background:

  • Cancer cachexia significantly reduces survival, treatment response, and quality of life.
  • Optimal care involves a multimodal strategy including nutrition, exercise, and pharmacotherapy.
  • This review focuses on recent evidence for pharmacologic interventions in cancer cachexia.

Purpose of the Study:

  • To review recent evidence supporting pharmacologic options for cancer malnutrition and cachexia.
  • To evaluate the efficacy and safety of various medications.
  • To provide guidance on first-line pharmacotherapy.

Main Methods:

  • Systematic review of recent evidence.
  • Analysis of studies and meta-analyses on pharmacologic agents.
  • Evaluation of safety and tolerability profiles.

Main Results:

  • Olanzapine demonstrated efficacy in appetite stimulation, weight gain, and reducing chemotherapy toxicity.
  • Evidence for steroids and progestogens is outdated, with potential to worsen cachexia.
  • Mirtazapine and DHA-containing fatty acids show low-level evidence.

Conclusions:

  • Pharmacotherapy for cancer cachexia has a limited role.
  • Olanzapine has the strongest evidence and should be considered first-line.
  • Olanzapine should replace steroids and progestogens in supportive oncology and palliative care.