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Early Coagulation Test Combined with Complete Blood Count in Diagnosis of Pulmonary Contusion and Fracture in

Xiao-Lu Wei

    Clinical Laboratory
    |July 7, 2026
    PubMed

    Insights

    Elevated D-dimer and lower activated partial thromboplastin time (APTT) levels, along with reduced hemoglobin (HB), can help differentiate pediatric pulmonary contusion from fractures. These early blood tests offer valuable diagnostic insights.

    Area of Science:

    • Pediatric Medicine
    • Hematology
    • Diagnostic Imaging

    Background:

    • Pulmonary contusion and fractures in children present diagnostic challenges.
    • Early and accurate differential diagnosis is crucial for appropriate pediatric patient management.

    Purpose of the Study:

    • To evaluate the clinical utility of combined early coagulation tests and complete blood count (CBC) for differentiating pediatric pulmonary contusion from fractures.

    Main Methods:

    • A cross-sectional study included 70 pediatric patients (35 with lung contusion, 35 with fractures).
    • Early coagulation parameters (PT, INR, APTT, FBG, TT, D-dimer) and CBC (HB, PLT) were analyzed within three hours of admission.

    Main Results:

    • Elevated D-dimer levels were significantly higher in pediatric patients with lung contusion (94.28%) compared to those with fractures (54.28%).
    • Lower APTT (14.28% vs. unspecified in fractures) and lower HB levels (68.57% vs. unspecified in fractures) were also more prevalent in the pulmonary contusion group.
    • These differences were statistically significant (p < 0.05).

    Conclusions:

    • D-dimer, APTT, and HB levels show diagnostic value in the early differential diagnosis of pediatric pulmonary contusion versus fractures.
    • Integrating coagulation tests with CBC aids in distinguishing these conditions in pediatric patients.
    Abstract

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