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Published on: July 5, 2021
Brugada syndrome in pregnancy
Shruti P Shirodkar1, Divya Mecheril Balachandran1, Vineeta Singh1
1Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Deoghar, India.
Summary
Brugada syndrome, a genetic heart condition affecting sodium channels, increases arrhythmia risk. Management involves avoiding triggers and ICDs, with generally favorable pregnancy outcomes.
Area of Science:
- Cardiology
- Genetics
- Electrophysiology
Background:
- Brugada syndrome is a rare inherited cardiac channelopathy.
- It affects cardiac sodium channels, primarily due to SCN5A gene mutations.
- This condition elevates the risk of syncopal attacks and potentially fatal arrhythmias.
Purpose of the Study:
- To provide a comprehensive overview of Brugada syndrome.
- To detail its pathogenesis, risk factors, and clinical manifestations.
- To discuss management strategies, particularly during pregnancy.
Main Methods:
- This study is a narrative review.
- It synthesizes information on Brugada syndrome from existing literature.
- The review covers pathogenesis, diagnosis, management, and outcomes.
Main Results:
- Various factors like fever, electrolyte imbalances, and drugs can precipitate Brugada syndrome.
- Management includes trigger avoidance, fever control, and ICD implantation for high-risk individuals.
- Pregnancy outcomes are typically favorable with multidisciplinary care.
Conclusions:
- Brugada syndrome requires careful management, focusing on precipitating factors and risk stratification.
- Pregnancy in affected individuals can be managed safely with a team approach.
- Further understanding of genetic and clinical aspects is crucial.
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