Related Concept Videos
02:51mRNA Stability and Gene Expression
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Cis-acting Elements involved in mRNA stability
02:51mRNA Stability and Gene Expression
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Cis-acting Elements involved in mRNA stability
01:53RNA Stability
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
01:53RNA Stability
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
01:17Gene Regulation During Sporulation
Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
01:23Regulation of Expression at Multiple Steps
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
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Related Experiment Video
Updated: Jul 8, 2026
07:18
Obtaining High-Quality Transcriptome Data from Cereal Seeds by a Modified Method for Gene Expression Profiling
Published on: May 21, 2020
Genes, Putative Long-Lived mRNAs and Pathways Underlying Genotypic Differences in Rice Seed Storability and Seed
Xiaoyu He1, Jiawei Ye1, Tingting Yu1
1College of Agronomy, Anhui Agricultural University, Hefei, China.
Rice (New York, N.Y.)
|July 7, 2026
Summary
This study reveals key genes regulating rice seed dormancy and storability, identifying OsGA2ox8 for dormancy and OsLEA5 for storability. These findings offer targets for improving rice quality and yield by managing pre-harvest sprouting and storage.
Area of Science:
- Plant Biology
- Genetics
- Agricultural Science
Background:
- Weak seed dormancy (SD) leads to pre-harvest sprouting, reducing rice quality and yield.
- Poor seed storability (SS) diminishes rice traits during post-harvest storage.
- The molecular link between SD and SS in rice remains largely unknown.
Purpose of the Study:
- To investigate the correlation between seed dormancy (SD) and seed storability (SS) in rice.
- To identify molecular genetic factors differentiating SD and SS.
- To provide targets for breeding rice with improved sprouting and storage characteristics.
Main Methods:
- Comparative transcriptomic and metabolomic analyses of two rice varieties (9311 and Nipponbare).
- Differential gene expression (DEG) and differentially accumulated metabolite (DAM) analysis.
- CRISPR/Cas9 gene editing for functional validation of key genes (OsGA2ox8 and OsLEA5).
Main Results:
- Nipponbare exhibited strong SD and poor SS, while 9311 showed the opposite.
- Identified 1,334 differentially expressed genes and 11 metabolic pathways commonly associated with both SD and SS.
- OsGA2ox8 was confirmed as a core regulator of SD, and OsLEA5 impacts SS.
Conclusions:
- Elucidated preliminary differentiation mechanisms between rice seed dormancy and storability.
- Identified OsGA2ox8 and OsLEA5 as crucial regulators for SD and SS, respectively.
- Provided potential targets for breeding rice varieties with enhanced pre-harvest sprouting resistance and superior seed storability.