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Updated: Jul 8, 2026

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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
Improved HIV Preexposure Prophylaxis Uptake in New York City
Emma Kaplan-Lewis1,2, Eunice Casey3, Chika Onyia4
1Clinical Quality Director of HIV, Hepatitis, and Sexual Health, Office of Ambulatory Care and Population Health, New York City Health and Hospitals, New York, NY, USA.
NEJM Catalyst Innovations in Care Delivery
|July 7, 2026
Summary
Implementing pre-exposure prophylaxis (PrEP) for HIV prevention in primary care increased uptake threefold. This patient-centered approach expanded access equitably to populations facing traditional barriers.
Area of Science:
- Public Health
- Infectious Disease Prevention
- Healthcare Systems Implementation
Background:
- Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention tool but faces underutilization and access inequities.
- Most eligible individuals receive care in primary settings, yet PrEP services are concentrated in specialty clinics.
- New York City Health and Hospitals (NYC H+H) identified a gap in primary care PrEP access.
Purpose of the Study:
- To address the underutilization and inequities in PrEP access within primary care settings.
- To develop and implement a patient- and care team-centered model for PrEP service delivery.
- To evaluate the impact of implementing PrEP services in a primary care setting.
Main Methods:
- A multidisciplinary working group convened to identify barriers and develop supports for PrEP implementation.
- Electronic medical record tools, customized training, and patient educational materials were developed.
- A pilot program was conducted from June to December 2023 at one primary care site in East New York, Brooklyn.
Main Results:
- PrEP uptake increased threefold among patients with a documented PrEP discussion (20%) compared to the system average (6.8%).
- The increase in PrEP uptake was observed across populations traditionally facing access barriers.
- The patient- and care team-centered approach facilitated equitable implementation of PrEP services.
Conclusions:
- Integrating PrEP services into primary care can significantly increase uptake and improve equitable access.
- A collaborative, needs-based approach involving care teams and patients is effective for implementing new clinical services.
- This model demonstrates a successful strategy for expanding HIV prevention services within large urban healthcare systems.

