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Self-Reported Tianeptine Experiences on Reddit: Natural Language Processing-Assisted Qualitative Study.

Christopher J Counts1, Anthony V Spadaro1, Sahithi Lakamana2

  • 1Department of Emergency Medicine, Rutgers New Jersey Medical School, 140 Bergen St, Newark, NJ, 07103, United States, 1 720-446-8235.

JMIR Infodemiology
|July 7, 2026
PubMed
Summary

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Discussions about tianeptine are rapidly increasing online. Many users report dependence, withdrawal, and co-use with other substances, indicating a significant public health issue.

Area of Science:

  • Pharmacology
  • Public Health
  • Digital Epidemiology

Background:

  • Tianeptine, an atypical antidepressant, is increasingly discussed on social media.
  • Concerns are rising regarding its potential for misuse and adverse effects.

Purpose of the Study:

  • To analyze online discussions to understand the emerging trends and public health implications of tianeptine use.
  • To identify patterns of tianeptine misuse, dependence, and co-ingestion with other substances.

Main Methods:

  • Natural language processing (NLP) was employed to analyze a large dataset of Reddit posts.
  • Manual thematic analysis was conducted to identify key themes and patterns in the discussions.

Main Results:

  • A significant increase in the volume of online discussions about tianeptine was observed.
Keywords:
Redditnatural language processingopioid use disordersocial mediasurveillancetianeptine

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  • Posts frequently detailed experiences of tianeptine dependence and withdrawal symptoms.
  • Co-ingestion of tianeptine with other unregulated substances was a common theme.
  • Conclusions:

    • Tianeptine represents an emerging public health concern due to widespread reports of misuse and dependence.
    • Online discussion analysis provides valuable insights into the real-world use and risks associated with tianeptine.
    • Further research and public health interventions are warranted to address the risks of tianeptine.