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Slice Collision-Induced Unfolding and Molecular Dynamics Reveal How Post-Translational Succination Reshapes SUMO1

Louis Groignet1,2, Thomas Robert1, Quentin Duez1

  • 1Organic Synthesis and Mass Spectrometry Laboratory, Department of Chemistry, Research Institute for Biosciences, University of Mons, Place du Parc 23, MonsB-7000, Belgium.

Journal of the American Society for Mass Spectrometry
|July 7, 2026
PubMed
Summary

Small ubiquitin-like modifier 1 (SUMO1) succination alters its structure and stability. Advanced ion mobility spectrometry-mass spectrometry reveals modified unfolding due to new interactions in succinated SUMO1.

Keywords:
(slice) collision-induced unfoldingSUMO1cyclic ion mobilitygas-phase unfoldingmolecular dynamicsnative (ion mobility) mass spectrometrysuccination

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