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Related Experiment Videos

Levofloxacin-Induced Cutaneous Adverse Reactions: Characteristics and Rational Use Strategies.

Liang Tian1, Shanshan Xu1, Hui Guo2

  • 1Department of Pharmacy, Shanghai Deji Hospital, Qingdao University, Shanghai, China.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|July 7, 2026
PubMed
Summary
This summary is machine-generated.

Levofloxacin antibiotic use can cause skin reactions. Most levofloxacin-induced cutaneous adverse drug reactions are mild, appear quickly, and resolve with treatment.

Related Experiment Videos

Area of Science:

  • Pharmacovigilance
  • Dermatology
  • Infectious Diseases

Background:

  • Levofloxacin, a fluoroquinolone antibiotic, is associated with various dermatological adverse drug reactions (ADRs).
  • Severe reactions like Stevens-Johnson syndrome can occur.
  • The China National Adverse Drug Reaction Monitoring System (CADRMS) collects pharmacovigilance data.

Purpose of the Study:

  • To evaluate levofloxacin-induced cutaneous ADRs reported to CADRMS in 2021.
  • To analyze the characteristics, manifestations, and outcomes of these reactions.

Main Methods:

  • Retrieved 2021 case reports of levofloxacin-associated cutaneous ADRs from CADRMS.
  • Included 35 cases with probable/possible causality after exclusions.
  • Performed descriptive analysis of patient demographics, drug administration, comorbidities, ADRs, and outcomes.

Main Results:

  • 35 patients (mean age 43.7 years; 60% male) experienced levofloxacin-induced cutaneous ADRs.
  • Most received intravenous levofloxacin (80%) for respiratory or urinary infections.
  • Reactions were predominantly mild (89%), including maculopapular rash, pruritus, and urticaria, with rapid onset (89% within 24 hours).

Conclusions:

  • Levofloxacin-induced cutaneous ADRs are generally mild, rapid-onset, and reversible.
  • Prompt discontinuation and supportive care, including antihistamines, lead to full resolution.
  • Rational prescribing involves allergy screening, monitoring IV administration, and cautious use in patients with comorbidities or polypharmacy.