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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
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Related Experiment Videos

Curbing Unnecessary Vitamin D Testing.

Reem Hasan1,2, Siouxzanna Downs3, Rasha Nakhleh4

  • 1Associate Professor of Medicine, Division of General Internal Medicine and Geriatrics, School of Medicine, Oregon Health and Science University, Portland, OR, USA.

NEJM Catalyst Innovations in Care Delivery
|July 7, 2026
PubMed
Summary
This summary is machine-generated.

Implementing electronic health record advisories significantly reduced low-value vitamin D testing. This clinical decision support intervention improved ordering appropriateness and achieved substantial cost savings without additional resources.

Related Experiment Videos

Area of Science:

  • Health Services Research
  • Clinical Informatics
  • Health Economics

Background:

  • Vitamin D testing is frequently overused in U.S. health systems, often outside evidence-based guidelines.
  • This overuse leads to significant costs and represents a low-value service in many regions.
  • Clear guidance from organizations like the Endocrine Society and CMS exists but is not consistently followed.

Purpose of the Study:

  • To reduce the volume of low-value vitamin D testing within an academic health system.
  • To improve the appropriateness of vitamin D test ordering through a clinical decision support intervention.
  • To assess the impact on testing rates, cost savings, and access to indicated testing.

Main Methods:

  • A multidisciplinary working group designed an electronic health record best practice advisory (BPA).
  • The BPA triggered at the point of order entry for vitamin D tests lacking approved indications, based on CMS coverage criteria.
  • The intervention was supported by communication, measurement infrastructure, and provider feedback mechanisms.

Main Results:

  • The proportion of indicated vitamin D tests increased from 45% pre-intervention to over 90% at one year post-implementation.
  • The total number of vitamin D tests decreased by 25.3%, resulting in an estimated cost savings of nearly $112,000.
  • Improvements were observed across various patient populations and care settings, with notable gains in outpatient and Medicaid populations.

Conclusions:

  • A targeted clinical decision support tool, combined with communication and measurement, effectively reduces low-value vitamin D testing.
  • The intervention improved ordering appropriateness while maintaining access to necessary testing, requiring no additional staffing or infrastructure.
  • Sustained improvement relies on transparent metrics, engaged leadership, and addressing ordering habits and clinical nuances.