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Updated: Jul 9, 2026
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
Rapid and real-time detection of trace BPA based on solution-gated graphene field-effect transistor by cerium-doped
Jiacheng Li1, Ting Li1, Lijun Wu1
1School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, Anhui, 230009, China.
Abstract:
Bisphenol A (BPA), as a synthetic organic pollutant, threatened the human body through food packaging, drinking water, and even skin contact. It could accumulate in the body and cause toxicological damage. Therefore, it was important to develop efficient and accurate BPA detection sensors. This study prepared cerium-doped ZIF-8 carbon materials (Ce@ZIF8/C) through doping bimetals on carbon-based metal-organic framework (MOF). The carbon material exhibited more mesopores and defect structures, and Ce effectively improved its electrochemical catalytic performance. The detection concentration range of the Ce@ZIF8/C-modified solution-gated graphene transistors was 30 nM to 1 μM, with a limit of detection (LOD) of 10 nM. The Ce@ZIF8/C-modified solution-gated graphene transistors could perform real-time detection of BPA in drinking water and milk samples, with detection accuracies of 114.59 ± 5.96% and 107.45 ± 3.75%, respectively. This indicated its potential for detecting BPA in drinking water and milk.
