Related Experiment Video
Updated: Jul 9, 2026
Cholinergic Ligand–dependent Modulation of Oxidative Phosphorylation Coupling in Digitonin-permeabilized BE(2)-C Neuroblastoma Cells
Published on: April 28, 2026
GLP-1 and MASH: When weight loss isn't the whole story
Michelle T Long1, Niels Krarup2, Filip K Knop2
1Novo Nordisk A/S, Bagsværd, Denmark; Department of Medicine, Section of Gastroenterology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
None:
Metabolic dysfunction-associated steatohepatitis (MASH) remains a major unmet clinical challenge. A new study by Gonzalez-Rellan et al.1 shows that glucagon-like peptide 1 (GLP-1) receptors on intrahepatic sinusoidal endothelial cells are key mediators of semaglutide's weight loss-independent hepatoprotective effects, reframing our understanding of how GLP-1-based therapies act within the diseased liver.
