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Understanding the physiological and psychological consequences of the GABAergic system in major depressive disorder
Xuan Yang1, Cong-Ya Chen1, Yu-Fei Wang1
1Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
Abstract:
Major depressive disorder (MDD) is a debilitating neuropsychiatric condition of complex multifactorial etiology, with pathophysiology increasingly attributed to disruptions in neuroendocrine homeostasis and central neurotransmitter signalling. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the brain that modulates multiple physiological and psychological consequences through gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors. GABAergic dysfunction, along with alterations in GABA levels and GABA receptor function, has been identified in MDD across animal and human studies. However, research on GABA in MDD is still relatively insufficient. Therefore, this review summarizes the GABAergic system in MDD and provides insight into these complex interactions.
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