Real-World Long-Term Outcomes of Rezūm Therapy for Large-Volume Benign Prostatic Hyperplasia: A Multicenter Cohort...

Area of Science:

• Urology
• Minimally Invasive Surgery
• Men's Health

Background:

• Benign prostatic hyperplasia (BPH) commonly causes lower urinary tract symptoms (LUTS) in aging men.
• Large prostates (≥80 mL) present challenges with severe symptoms and limited treatment options.
• Water vapor thermal therapy (Rezūm) shows promise for moderate glands, with emerging data for larger ones.

Purpose of the Study:

• To evaluate the long-term effectiveness of Rezūm therapy in men with large prostates (≥80 mL).
• To assess changes in urinary status, sexual function, and prostate size in a real-world, multicenter cohort.
• To provide extended follow-up data on Rezūm therapy for large-volume BPH.

Main Methods:

• Retrospective analysis of a prospectively maintained multicenter registry (Canada & Italy).
• Included patients with baseline prostate volume ≥80 mL treated with Rezūm.
• Assessed outcomes (IPSS, QoL, Qmax, PVR, sexual function) at 6, 12, 24, and 36 months.

Main Results:

• 321 patients included; mean prostate volume 107 mL.
• Significant IPSS reduction (62%) and QoL improvement at 36 months (p<0.001).
• Improved Qmax, decreased PVR, and preserved sexual function; 29.9% prostate volume reduction at 12 months.

Conclusions:

• Rezūm therapy offers significant, durable improvements for urinary symptoms and function in men with large prostates.
• The therapy is safe and effective in real-world practice, preserving sexual function.
• Supports Rezūm as a viable minimally invasive option for large-volume BPH.