Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Study Design in Statistics01:15

Study Design in Statistics

A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Situ Probing of Early Stage Phase Transformation of KCl in Aqueous Solutions via Liquid-Cell TEM.

Nano letters·2026
Same author

Integrating lung microbiome, amino acid metabolism, and host immune response in elderly patients for severe lower respiratory Infections diagnosis: a multi-omics study.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

General Oxidative Chemical Activation of Neutral Exciton Emission in Colloidal MoS<sub>2</sub> Monolayers.

Journal of the American Chemical Society·2026
Same author

Author Correction: Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish.

Nature communications·2026
Same author

Applying Artificial Intelligence and machine learning in precision nutrition.

Nature communications·2026
Same author

Development of a CRISPRi system in <i>Fusarium fujikuroi</i> and its application in gibberellic acid production.

Engineering microbiology·2026

Related Experiment Video

Updated: Jul 9, 2026

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
07:14

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models

Published on: December 23, 2025

Empowering clinical trial design with agentic intelligence and real-world data.

Haoyang Li1, Weishen Pan1, Suraj Rajendran2

  • 1Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.

Nature Communications
|July 7, 2026
PubMed
Summary

EmulatRx accelerates clinical trial design by using artificial intelligence to extract real-world evidence from electronic health records. This agentic framework refines trial protocols autonomously, improving efficiency and outcomes.

Related Experiment Videos

Last Updated: Jul 9, 2026

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
07:14

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models

Published on: December 23, 2025

Area of Science:

  • Biomedical Informatics
  • Artificial Intelligence in Healthcare
  • Clinical Trial Design

Background:

  • Clinical trial design (CTD) is complex and requires significant expertise.
  • Real-world data (RWD), like electronic health records (EHR), contains valuable practice-based evidence for CTD.
  • Existing machine learning methods for extracting real-world evidence (RWE) require extensive expert collaboration.

Purpose of the Study:

  • To introduce EmulatRx, an agentic framework for deriving RWE to aid CTD.
  • To demonstrate EmulatRx's ability to autonomously refine trial protocols and generate actionable insights.
  • To evaluate EmulatRx's effectiveness in facilitating and accelerating the CTD process.

Main Methods:

  • Developed EmulatRx, an agentic framework utilizing iterative conversations and role-based agent analysis.
  • Applied EmulatRx to CTD for acute diseases (septic shock, heart failure, etc.) using MIMIC-IV data.
  • Applied EmulatRx to CTD for chronic diseases (Alzheimer's, Parkinson's) using the INSIGHT Network data.

Main Results:

  • EmulatRx autonomously refines trial protocols through iterative agent interactions.
  • The framework generates robust reports with insights to inform CTD.
  • Successful application demonstrated on diverse disease types (acute and chronic) across multiple health systems.

Conclusions:

  • EmulatRx effectively facilitates and accelerates the clinical trial design process.
  • The agentic framework shows promise in leveraging RWE for improved CTD.
  • EmulatRx represents a significant advancement in AI-driven clinical trial development.