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FOXQ1 promotes endometriosis development by enhancing mitochondrial function.
1Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, P. R. China.
Biological Research
|July 8, 2026
Summary
FOXQ1 promotes endometriosis by boosting mitochondrial function, increasing inflammation, and driving cell growth and spread. This discovery offers new insights into endometriosis pathogenesis.
Area of Science:
- Gynecological pathology
- Molecular biology
- Cellular biology
Background:
- Endometriosis (EMs) is a condition where endometrial tissue grows outside the uterus.
- The role of FOXQ1 in endometriosis pathogenesis and its impact on mitochondrial function require investigation.
Purpose of the Study:
- To investigate the role of FOXQ1 in endometriosis pathogenesis.
- To explore the regulatory effect of FOXQ1 on mitochondrial function in endometriosis.
Main Methods:
- Analyzed FOXQ1 expression in patient samples (endometrial, ovarian, pelvic sidewall, bowel EMs) using RT-qPCR and Western blot.
- Assessed inflammatory cytokine levels (IL-6, IL-1β, TNF-α, IL-8) and mitochondrial function (mtDNA, ATP, ROS, OCR, MitoTracker) in primary human endometrial epithelial cells (hEECs) with FOXQ1 manipulation.
- Evaluated in vitro effects on apoptosis, proliferation, invasion, and migration in hEECs.
Main Results:
- FOXQ1 expression was significantly elevated in endometriotic lesions compared to controls.
- Overexpression of FOXQ1 in hEECs inhibited apoptosis, upregulated inflammatory cytokines, and promoted proliferation, invasion, and migration.
- Enhanced mitochondrial function (increased mtDNA, ATP, ROS, OCR) was observed with FOXQ1 overexpression, while knockdown showed opposite effects. ROC analysis indicated FOXQ1's diagnostic potential (AUC=0.8784).
Conclusions:
- FOXQ1 plays a crucial role in facilitating endometriosis progression.
- Enhanced mitochondrial function by FOXQ1 stimulates inflammatory responses and promotes key cellular processes in endometriosis.
- FOXQ1 is a potential therapeutic target for endometriosis.
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