Related Experiment Video
Updated: Jul 9, 2026

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
Published on: July 25, 2012
The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described?
Daniela Negrini1, Giuseppe Miserocchi2
1Department of Medicine and Technological Innovation (DIMIT), University of Insubria, Varese, Italy.
None:
The proposal of a "new third bodily system for circulation of fluid" has been recently put forward. The present article sheds light on all available physiological knowledge concerning exactly this same space, defined as "interstitial compartment" as originally hypothesized by Ernest Starling about 130 years ago. We provide here a brief updated summary of the main morpho-functional features and corresponding analysis concerning capillaries microfiltration, interstitial fluid dynamics, and lymphatic drainage.
Related Concept Videos
Fluid Movement Between Compartments
Composition of Body Fluids
Body Water Content and Fluid Compartments
Compartment Models: Single-Compartment Model
Capillary Exchange
Compartment Models: Two-Compartment Model
