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Related Experiment Video

Updated: Jul 9, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
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Global Rather Than Vertical-Selective Saccadic Abnormalities in Progressive Supranuclear Palsy.

Duy Duan Nguyen1,2,3, Mark Paine4, Soohyun Lee1

  • 1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.

Annals of Clinical and Translational Neurology
|July 8, 2026
PubMed
Summary

Vertical saccades are not selectively impaired in Progressive Supranuclear Palsy (PSP). Findings reveal a global disruption of the saccadic system, not specific vertical saccade deficits.

Keywords:
Lewy body diseaseeye movementsprogressive supranuclear palsysaccades

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Area of Science:

  • Ophthalmology
  • Neurology
  • Movement Disorders

Background:

  • Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease.
  • Clinical observations suggest vertical saccades are particularly affected in PSP.

Purpose of the Study:

  • To investigate whether vertical saccades are preferentially impaired in Progressive Supranuclear Palsy (PSP).
  • To compare saccadic metrics between PSP patients, controls, and other neurodegenerative diseases.

Main Methods:

  • Compared 24 PSP patients to 94 controls and patients with Alzheimer's disease (n=20) and Lewy body disease (n=50).
  • Utilized video-oculography to measure visually guided saccades in vertical and horizontal planes.
  • Analyzed traditional velocity metrics alongside novel measures of velocity interruption, vacillation, and directional instability.

Main Results:

  • Vertical saccades were slower than horizontal across all groups, including controls.
  • PSP patients showed significantly slowed saccade velocities in both vertical and horizontal directions.
  • While vertical saccades showed more disorder than horizontal in controls and PSP, no specific predilection for vertical saccade impairment was found in PSP.

Conclusions:

  • Vertical saccades are not selectively impaired in Progressive Supranuclear Palsy (PSP).
  • The study indicates a more generalized disruption of the saccadic system in PSP.
  • The apparent clinical deficit in vertical saccades in PSP likely stems from their baseline slower speed and increased disorder compared to horizontal saccades.